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Taxonomic Class-home remedy
Lamiaceae
Common Trade Names
Tonka bean
Common forms
Tonka bean is difficult to obtain commercially, the availability is rare.
Source
Active components are extracted from the fruits and seeds of Dipteryx odorata a tree that is native to South America, particularly Brazil and Venezuela. The tonka bean tree belongs to the family of legumes.
Chemical Components
The primary chemical components of tonka bean are coumarin, dihydrocoumarin, and o-coumaric acid. Other components include melilotic acid melilotate methyl, Ethyl melilotate, 5-HMF, fat and starch.
Actions
Coumarin is inside the body to 7-hydroxy-metabolism, which then glucuronidation in the intestine and liver, this extensive first-pass metabolism results in low absolute bioavailability of coumarin. Both coumarin and 7-hydroxy have the growth of selected Types of malignant human cell lines inhibited vitro. The glucuronide metabolite of 7-hydroxy-seems to be inactive.
Reported Uses
Tonka bean is claimed To relieve abdominal cramps and nausea; The fruit is also thought to act as an aphrodisiac. It is, as a folk remedy for whooping cough are known. Coumarin has long been considered Flavoring agent in foods and fragrances used in pharmaceutical products. It has shown therapeutic benefit against lymphedema in clinical trials.
Dosage
The usual dose is used, 60 mg coumarin PO daily. (Some studies have doses are based on the coumarin of the product.)
Adverse Reactions
CV: potential cardiac side effects () with large doses.
Hepatic: hepatotoxicity.
Interactions
Anticoagulants: Can heavy bleeding. Avoid administration with tonka bean.
Drugs that cause hepatotoxicity: the risk of additive toxicity. Avoid administration with tonka bean.
Contraindications and precautions
Tonka bean is contraindicated in patients with underlying liver dysfunction because of the potential for toxicity. Avoid They use in pregnant or lactating female patients, the effects are not known.
Special Considerations
Inform the patient, the tonka bean the FDA is on the list of unsafe herbs.
Advising patients to consult a doctor before and herbal preparations because a treatment that is clinically investigated and shown to be effective, are available.
Monitor liver function test results.
Avoid advising women with tonka bean during pregnancy or while breastfeeding.
Points of Interest
Bishydroxycoumarin Please Do not confuse this herb with the synthetic anticoagulant.
Excerpts from tonka beans were used as a condiment and for castor oil preparations.
Comment
Several tonka bean components especialIy Coumarin and 7-hydroxy-, show promising future therapeutics. Given the absence of the efficacy and safety data, the herb can not be recommended for each drug.
About the Author
Author is a professional writer on various topics like common ailments and ayurvedic treatment. He is also proficient in writing about herbal treatments. I hope you like the articles.
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